EMMA

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EMMA Endometrial Microbiome Metagenomic Analysis

The most comprehensive and precise panel, encompassing the most frequently detected and clinically relevant bacteria to evaluate the endometrium at the microbiological level

30% of infertile women have pathogenic bacteria in their endometrium

Upgraded EMMA panel: the most precise panel available, developed after analyzing over 70,000 clinical samples during the last 5 years

The upgraded EMMA panel now identifies bacteria at the species level, enabling more precise and targeted treatments

Many women undergoing IVF are unable to get pregnant, even after transferring good-quality embryos. Although a good-quality embryo is an important starting point, it is also important to transfer the embryo into a uterus that is in the healthiest state possible.

What is the endometrium and why does it matter?

> The endometrium is a tissue lining the interior of the uterus where the embryo implants and resides during pregnancy. Each month, the endometrium prepares for the arrival of an embryo. When this does not occur, menstruation begins.

> Problems with the endometrial lining are one of the leading causes of infertility in women. A healthy endometrium is rich in healthy bacteria: the endometrial flora. Infections with harmful bacteria can cause diseases of the endometrium, such as chronic endometritis.

 

What is endometrial flora?

 The endometrial flora or microbiome is the sum of the microorganisms and their collective genetic material present in the endometrium.

What is EMMA test?

EMMA evaluates your endometrial microbiota detecting the most common bacteria present in the endometrium, including the good ones.

EMMA also includes the ALICE test to identify the pathogenic bacteria most commonly associated with chronic endometritis.

We are then able to recommend the best probiotic and/or antibiotic treatment to balance your endometrial flora, improving your pregnancy prospects.

We have analyzed more than 70,000 clinical samples during 5 years of experience.

Thanks to our experience with EMMA&ALICE tests, we know which are the most often bacterial pathogens detected in the endometrium.

Based on this data, we have designed the most comprehensive and precise panel, encompassing all clinically relevant bacteria, with most identified at the species level, enabling more precise and targeted treatments.

Why use EMMA – Endometrial Microbiome Metagenomic Analysis?

> EMMA uses RT-PCR technology to provide endometrial microbiome information by analysing the presence and quantity of the most common and relevant bacterial pathogens of the reproductive tract.

> EMMA can also determine the abundance of Lactobacillus present in the endometrium; low proportions of Lactobacillus is associated with poor reproductive outcomes.

> EMMA also includes ALICE, which detects pathogenic bacteria that can cause chronic endometritis.

> EMMA determines whether the endometrial microbial environment is optimal or not for embryo implantation.

> If the endometrial microbial environment is not optimal for embryo implantation, a recommendation for a precise and targeted treatment is provided.

Is EMMA for you?

This test is recommended if:

> If you want to become a mother, you can benefit from the greater knowledge about your endometrium that the EMMA test offers

> This test is especially useful if you have suffered recurrent implantation failures or repeated miscarriages during your IVF cycles.

EndomeTRIO

by with No Comment Patients

EndomeTRIO: Your endometrium matters

A complete view of endometrial health to help you in your reproductive journey

EndomeTRIO includes ERA, EMMA, and ALICE test

The ERA test resulted in a 73% pregnancy rate in patients with implantation failure

30% of infertile women have pathogenic bacteria in their uterus

Why does the endometrium matter?

The endometrium is a tissue lining the interior of the uterus where the embryo implants and resides during pregnancy. Each month, the endometrium prepares for the arrival of an embryo. When this does not occur, menstruation begins.

Variations of the endometrium are one of the leading causes of infertility in women. The endometrium must be both receptive to embryo implantation at the time of transfer and rich in healthy bacteria. Infections with harmful bacteria can cause diseases of the endometrium, such as chronic endometritis, which are associated with poor reproductive outcomes.

Recent studies led by Igenomix indicate that the endometrium is a key factor for reproductive success. 20% of infertility is caused by the endometrial factor.

What is Endome TRIO?

EndomeTRIO is a complete endometrial analysis that includes ERA, EMMA and ALICE tests.

> EndomeTRIO provides a complete view of your endometrial health.

> ERA will enable you to perform a personalized embryo transfer, increasing the likelihood of successful implantation and a successful pregnancy

> EMMA will determine whether the uterine microbial environment is optimal for embryo implantation.

> If ALICE detects pathogenic bacteria, appropriate antibiotics, and probiotic treatments will be recommended to treat chronic endometritis

ERA

by with No Comment Patients

Endometrial Receptivity Analysis (ERA)​

Maximize your chances of pregnancy without losing good embryos

3 in every 10 women have a displaced window of implantation

Many women undergoing IVF are unable to get pregnant, even after transferring good quality embryos. Although a good quality embryo is an important starting point, it is also important to transfer the embryo into a uterus that is ready to receive the embryo.

 

> The timing of embryo transfer must be coordinated with your body´s menstrual cycle, neither too early nor too late, but at just the right time. For most women, the best time to transfer an embryo it´s the same, but for some women, it can be different.

What is the Endometrium?

> The interior of the uterus is lined with a tissue called endometrium, which is prepared each month for the arrival of an embryo and it’s the nest where the embryo implants and resides during gestation. Even the best embryo will fail to implant if conditions aren’t right.

What is Endometrial receptivity?

> The endometrium is receptive when it is ready for embryo implantation to occur. This period of receptivity is called the window of implantation.

> Each woman has a unique window. For some women, the window is shorter and/or displaced. By knowing your window of implantation, you can optimize your chances of pregnancy through a personalized embryo transfer.

What is the ERA test?

> ERA evaluates endometrial receptivity, the optimal time for embryo transfer that is specific for each woman.

Why use ERA?

> When performing the embryo transfer in a personalized way, the chances of getting pregnant are increased after the assisted reproduction treatment

> Maximize your chances of pregnancy and don’t lose good embryos.

> 7 in 10 women gave birth after 1 year.

> A recent randomized study proves that a personalized embryo transfer is superior to the classic frozen embryo transfer.

Is ERA® Endometrial Receptivity Analysis for you?

> ERA test is indicated for patients with implantation failure of endometrial origin.

> Clinical studies, at different stages of development, are exploring the indication for ERA in first-visit IVF patients.

ERA Test Results

A RECEPTIVE RESULT

A receptive result shows that the window of implantation is ‘open’ at the time and day of taking the sample and the recommendation is to proceed with embryo transfer under the same conditions as the biopsy.

A NON–RECEPTIVE RESULT

A non-receptive result shows a displaced window of implantation. In this case, with the ERA computational predictor, we will estimate your window of implantation indicating when your personalized embryo transfer is optimal in 90% of the cases. A second biopsy will be needed in only 10% of cases.