PGT-A Preimplantation Genetic Testing for Aneuploidies

Improves the chances of reproductive success by selecting chromosomally normal embryos

Proprietary Artificial
Intelligence algorithm

98% accuracy

Superior reviews from
independent studies

What is PGT-A test?

> PGT-A (formerly PGS) is a genetic test performed on embryos to identify numerical chromosomal abnormalities (aneuploidy).

> Our PGT-A uses Next-Generation Sequencing (NGS), which allows us to analyze all 24 chromosomes. Chromosomal abnormalities are detected prior to embryo transfer to enable informed decisions and increase pregnancy success.

Clinical outcomes with and without PGT-A based on SART 2016 public database
 

What is the Procedure?

Why use PGT-A Preimplantation Genetic Testing for Aneuploidies?

> Increases pregnancy rates per transfer:
Selecting normal embryos can increase the pregnancy chances after transfer

> Reduction in miscarriage rate:
In the general population, 25% of all clinical pregnancies end in miscarriage, the vast majority of which are due to aneuploidy

> Increase in the likelihood of having a healthy baby:
Some pregnancies with chromosomal anomalies can give rise to the birth of baby with a serious illness

> Reduction in time and necessary resources:
The time and resources necessary to achieve a pregnancy are reduced

> Reduces risk of multiple pregnancy:
A SET significantly reduces the likelihood of a twin pregnancy

Who should use PGT-A?

> PGT-A is particularly important for patients over 35, as aneuploidy rate increases with maternal age from approximately 52% at maternal age under 35, to approximately 80%, at age 42.

> PGT-A also can greatly reduce the likelihood of a patient having a multiple-gestation pregnancy by choosing a Single Embryo Transfer (SET).

Test limitations

PGT-A does not test for:

> Birth defects
> Inherited single gene disorders, such as cystic fibrosis or Tay-Sachs disease
> Multifactorial conditions, including autism
> Adult-onset conditions such as diabetes or Alzheimer´s disease
> Physical and mental traits, such as intelligence or athleticism
> Microdeletions/microduplications

As with most tests, PGT-A has some limitations:

1. Accuracy is ~98%

> False positive: There is a small chance an embryo could be excluded unnecessarily

> False negative: There is a small chance that an embryo diagnosed as normal could still be chromosomally abnormal

2. PGT-A tests only the samples produced by embryo biopsy, not whole embryos

3. PGT-A does not detect structural abnormalities that do not involve gains or losses of genetic material. Additionally, the following cannot be detected:

> Chromosome losses/gains bellow 10Mb,

> Low level of mosaicism (<30%)

> Uniparental disomy (UDP)

> Defects affecting the complete set of chromosomes (haploidy, triploidy)

Follow-up prenatal testing is recommended to confirm the results of PGT-A.

There is a chance of unforeseeable problems with transportation, such as weather and air travel issues, or other circumstances beyond the control of Igenomix that may delay the reporting of results.

In a small percentage of cases, genetic testing cannot be performed due to improper biopsy techniques, loss of biopsied cells, or poor DNA quality.

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