EndomeTRIO: The endometrium matters

A new dimension of endometrial health to improve the reproductive prognosis of your patients.

EMMA + ALICE + ERA

A better understanding of endometrial health to improve reproductive prognoses

30% of infertile women have pathogenic bacteria

What test does the EndomeTRIO analysis include?

Endometrial Receptivity Analysis

> The ERA test evaluates the stage of an endometrium to determine if a receptive or non-receptive genetic profile is present at the time of biopsy.

Endometrial Microbiome Metagenomic Analysis

> A screening test to evaluate the endometrium at the microbiological level.

Analysis of Infectious Chronic Endometritis

> ALICE detects the bacteria causing chronic endometritis to improve your patient’s reproductive prognosis.

What is the procedure?

Why does the endometrium matter?

> The endometrium has been noted as a key factor for a healthy pregnancy in recent scientific studies.

> Since 2011, Igenomix has been conducting a deep line of research to understand the role of the endometrial factor in recurrent implantation failure patients.

> Our recent publications in the American Journal of Obstetrics and Gynecology (AJOG) demonstrate a new dimension of endometrial health that can improve your patient’s reproductive prognosis.

 

Why use EndomeTRIO test?

> A better understanding of endometrial health to improve your patient’s reproductive prognosis: Analyses Endometrial receptivity, chronic endometritis and endometrial flora.

> EndomeTRIO uses the latest Next Generation Sequencing technology.

Who should use EndomeTRIO Analysis?

> Women who have experienced implantation failure with morphologically good quality embryos

> Women with a history of recurrent pregnancy loss

> Women who have an atrophic endometrium (< 6mm) present higher risk of having a displaced WOI.

> Women with Chronic Endometritis

ERA Test limitations

> There is a risk (<5%) to get a non-informative result, in which the biopsy procedure has failed to obtain a sufficient quantity and/or quality of tissue to be able to make a diagnosis. If this should occur a new biopsy will be required.

> Pregnancy is not guaranteed, even with a receptive result. Poor embryo quality, genetic abnormalities, or previous pathologies can also reduce the likelihood of becoming pregnant.

> The ERA® does not test for any other endometrial pathology and does not asses or provide a prediction for the health of a subsequent pregnancy.

EMMA/ALICE Limitations

> These tests are not able to detect resistance to antibiotics.

> ALICE only detects the presence of pathogens associated with chronic endometritis.

> A negative result does not rule out the presence of other endometrial pathogens.

> The tests are not 100% accurate at determining the bacterial species.

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