NACE Non-invasive prenatal test

Non-invasive prenatal screening helps to avoid unnecessary amniocentesis

Highest informativity rate in the market: we obtain results for 99.9% of the analyzed samples

Available from week 10 of pregnancy

Reduces unnecessary amniocentesis

What is NACE?

NACE is a non-invasive prenatal screening test for the most frequent chromosomal abnormalities. The test is non-invasive, meaning that there is no risk to the fetus.

A simple blood draw from the mother allows free fetal DNA circulating in the maternal bloodstream to be detected via next-generation sequencing (NGS) technology and our proprietary bioinformatic analysis tool.

Methodology

What does NACE detect?

> NACE detects abnormalities in chromosomes 21, 18, 13 and the most common anomalies in the sexual chromosomes (X and Y).

> NACE 24 analyzes all chromosomes

> NACE 24 Extended analyzes all 24 chromosomes and identifies microdeletions associated with 6 major genetic syndromes.

NACE can be used for:

> Single pregnancies

> Twin pregnancies

> Can give results with fetal fraction under 4%

> Natural conception

> IVF

> Egg donation

> Women of all ages

> Women of all ethnicities

> Women of all body mass index

> Suitable for cases of consanguinity

Why use a non-invasive prenatal test

> Prevent the need for 98% of invasive tests in patients at risk for trisomy 21 (Down Syndrome)

> Reduces the number of miscarriages caused by amniocentesis or chorionic villus sampling (CVS)

> Can give results with fetal fraction under 4%

> NACE has the highest informativity rate in the market: we obtain results for 99.9% of the analyzed samples

> NACE Extended 24 incorporates the detection of all 24 chromosomes and identifies five microdeletions that are associated with major genetic syndromes

> More reliable than 1st trimester combined screening. The false positive rates of conventional tests, including biochemical screening, mean that 1 in every 20 women who test positive for Down syndrome will actually be carrying a healthy baby.

> Avoid a false sense of security: Of every 20 women carrying a baby with Down syndrome, 3 will test negative by biochemical screening.

Who is NACE suitable for?

Several scientific studies support the use of non-invasive prenatal testing for all pregnant women.

> An abnormal result in their first-trimester screen.

> A previous Down´s syndrome pregnancy

> A suspicious ultrasound finding.

Test Limitations

> cfDNA screening is considered a screening test and not a diagnostic test. 

> False non-invasive prenatal screening (NIPT) results: fetoplacental mosaicism, maternal chromosomal abnormalities, vanishing twin syndrome and/or errors associated with the procedures. 

> Low-molecular-weight heparin can interfere with the analysis. If the patient is taking heparin during pregnancy, the recommendation is to perform the blood draw before heparin administration. 

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