ALICE Analysis of Infectious Chronic Endometritis

ALICE detects the bacteria causing chronic endometritis to improve your patient’s reproductive prognosis

20% of infertility is caused by the endometrial factor.

Chronic endometritis affects up to 30% of infertile patients.

In cases of RIF or recurrent pregnancy loss, chronic endometritis can rise to 66%

What is ALICE test?

> ALICE is a test that detects pathogenic bacteria and recommends adequate treatment.

> Pathogenic bacteria cause chronic endometritis, which is linked to implantation failure and recurrent miscarriage.

> In cases of repeated implantation failure or recurrent pregnancy loss, chronic endometritis can rise to 66%.

What is the procedure?

> ALICE can be performed on a small piece of an endometrial biopsy.
 

Why use ALICE?

> ALICE is a diagnostic test to detect and quantify the most common pathogenic bacteria causing chronic endometritis, recommending appropriate antibiotic and probiotic treatment

> ALICE uses the latest Next Generation Sequencing (NGS) technology to provide microbiome information in endometrial tissue by analysing the abundance of specific bacteria causing chronic endometritis

> Using NGS allows the identification of culturable and nonculturable endometrial pathogens associated with chronic endometritis

> If the ALICE test is positive, the report will focus on the detection of the specific bacteria causing the condition

> A recommendation of the most appropriate antibiotics is made based on the bacteria detected.

> Microbiology counselling is available

 

Who should use ALICE?

> ALICE can be beneficial for any patient wishing to conceive, by assessing the microbiological environment that the embryo will encounter at implantation.

> ALICE may also be beneficial for patients with a history of recurrent pregnancy loss or recurrent implantation failure because chronic endometritis has been linked to these events.

Test limitations

> This test is not able to detect resistance to antibiotics.

> ALICE only detects the presence of pathogens associated with Chronic Endometritis. A negative result doesn’t rule out the presence of other endometrial pathogens.

> This test is not 100% accurate at determining the bacterial species.

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